Schwere Panzerabteilung 501 was sent to North Africa following the Allied landings in Northwest Africa. The first tanks arrived in Tunisia in November 1942 while the second kompanie, was used for the occupation of Vichy France. It surrendered in Tunisia in May 1943 but was reformed later in September 1943 from the cadre of troops that had been withheld from Africa.
Following the Allied landing in French North Africa the battalion, with its 16 Panzer IIIs, arrived in Tunisia between November 1942 and January 1943.
Initially only three Tiger Is of the 501st landed at Tunis on November 23rd, 1942. These first elements of the battalion, along with four Panzer IIIs, were organized with other units into Kampfgruppe Lueder. They were involved in fighting just over a week later during the Axis counterattack on 1 December, destroying nine US and two British tanks on the first day while relieving German forces. On December 2nd, KG Lueder, with one Tiger and five Panzer IIIs, attacked Tebourba, stopping an Allied advance and knocking out six tanks and four anti-tank guns for the loss of three Panzer IIIs. On 3 December, the single operational Tiger I was reinforced by three newly arrived Tigers, which, with infantry support, surrounded Tebourba. The next day, with Junkers Ju 87 Stuka aircraft support, Kampfgruppe Lueder took Tebourba but was then disbanded, all of its Tigers being out of action. Of 182 tanks present, the Allies lost 134.
Reinforcements of one Tiger and one Panzer III arrived on December 9th, which along with repairs of battle damage, gave an inventory of seven Tiger Is and five Panzer IIIs. The next day, they moved together with elements of 10th Panzer Division on the road to Massicault, attacking towards Majaz al Bab, gaining 13 km (8.1 mi) and destroying 14 M3 Stuart tanks. The next day, they covered the southern flank of the main attack and acted as a reserve element, 7 km (4.3 mi) east of Djedeida.
By the end of December 1942, strength was up to 11 out of 12 Tigers operational, plus 16 Panzer IIIs. On 15 January 1943, eight Tigers and eight Panzer IIIs were assigned to work with 756th Mountain Infantry Regiment, KG Lueder was re-established with five Tigers and 10 Panzer IIIs plus the 1st battalion of the 69th Mechanized Infantry Regiment. On January 18th, as part of Operation Eilbote I, the mountain infantry broke through enemy positions which were protected by anti-tank mines, and captured a crossing south west of Lake Kebir; one Tiger was scrapped due to a shortage of spare road wheels after hitting a mine. On January 19th, KG Lueder attacked along the road towards Robaa, then turned and took the crossing at Hir Moussa, capturing US personnel carriers which were turned over to their infantry. Skirmishes on January 20th resulted in the loss of a Tiger to a British 6 pdr anti-tank gun, and another blown up by British engineers. Over the next two days, British counterattacks were repelled; three enemy tanks destroyed for the loss of two Panzer III and one Tiger. On January 24th, more British attacks were repelled with heavy German losses.
14 Panzer IIIs plus 11 out of 16 available Tigers were operational on January 31st, 1943. They were split between the 756th and 69th again; under KG Weber they began Operation Eilbote II, but it was stopped by strong anti-tank defenses and minefields, then withdrew. Tiger armor was penetrated for the first time, two were knocked out; one burnt and was unrecoverable.
The six Tigers and nine Panzer IIIs of the 1st Company of the 501st were attached to 10 Panzer Division on 8 February for Operation Fruhlingswind. After night marches, they joined KG Reimann near Bou Thadi on 13 February. The next day, they broke through the Faïd Pass and joined the Battle of Sidi Bou Zid. Tigers knocked out 20 M4 Sherman tanks of the US 1st Armored Division. On February 26th, the 501st was re-designated III./Panzer-Regiment 7 of 10 Panzer-Division at the end of the Battle of the Kasserine Pass. Each company received 15 Panzer IVs as reinforcement.
The battalion that took part in the Axis offensive of Operation Ochsenkopf on February 27th. However it was stalled by numerous artillery bombardments, air attacks and mud. One Tiger also hit a mine. Continuing the attack overnight, seven more Tigers were immobilized by mines and Major Lueder was wounded. The next day, March 1st, all of the immobilized tanks were blown up, leaving one operational Tiger. The offensive failed with huge tank losses so much so that 501st had ceased to be an effective fighting force.
Over the next few days, more tanks were made operational, reaching six Tigers, 12 Panzer IIIs and seven Panzer IVs by March 10th. On March 17th, the remnants (11 Tigers) of the 501st were attached to the 504th, which had just arrived. On May 12th, 1943, the 501st were among over 230,000 Axis soldiers who surrendered at the end of the Tunisia Campaign following the Allied capture of Tunis.